Picture

Northwestern Medicine
​Breakthroughs for Physicians

​​
  • Home
  • Specialties
    • Cardiovascular >
      • Research
      • Clinical Breakthroughs
      • News
    • Endocrinology >
      • Clinical Breakthroughs In Endocrinology
      • Research In Endocrinology
      • News
    • ENT (Otolaryngology) >
      • Clinical Breakthroughs
      • Research
      • News
    • Gastroenterology >
      • Clinical Breakthroughs
      • Research
      • News
    • Geriatrics >
      • Clinical Breakthroughs
      • Research
      • News
    • Neurosciences >
      • Rare and Complex Brain Tumors
      • Research
      • COVID-19 and Neurosciences
      • News
      • Clinical Breakthroughs
    • OB-GYN >
      • Clinical Breakthroughs
      • Research
      • News
    • Oncology >
      • Clinical Breakthroughs
      • Research
      • News
    • Ophthalmology >
      • Clinical Breakthroughs
      • Research
      • News
    • Organ Transplant >
      • Clinical Breakthroughs
      • Research
      • News
    • Orthopaedics >
      • Clinical Breakthroughs
      • Research
      • News
    • Psychiatry >
      • Clinical Breakthroughs
      • Research
      • News
    • Pulmonary >
      • Clinical Breakthroughs
      • Research
      • News
    • Rehabilitation >
      • Clinical Breakthroughs
      • News
    • Rheumatology >
      • Clinical Breakthroughs
      • Research
      • News
    • Urology >
      • Clinical Breakthroughs
      • Research
      • News
  • CME
  • REFERRALS
    • Refer to NM Cardiovascular
    • Refer to NM Neurosciences
    • Refer to Other Specialties

< BACK TO RESEARCH IN RHEUMATOLOGY

July 2022

RHEUMATOLOGY

YVONNE C. LEE, MD, RECEIVES INNOVATIVE RESEARCH AWARD FROM RRF

Congratulations to Yvonne C. Lee, MD, MMSc, of Northwestern Medicine Rheumatology, on receiving the 2022 Innovative Research Award from the Rheumatology Research Foundation. This award encourages independent investigators to conduct novel studies that generate new insights into the cause, progression, treatment and outcomes of rheumatic diseases.
 
Transcriptional Profiles of Circulating Monocytes and Their Association With Pain Centralization and DMARD Response in Rheumatoid Arthritis
 
Among patients with rheumatoid arthritis (RA), pain may persist even when inflammation is controlled. This pain may be due to pain centralization, a process that changes the way the brain and spinal cord regulate pain.
 
The goal of this proposal is to develop insights into the processes underlying pain centralization by studying the relationship between gene expression in monocytes (a type of white blood cell) and pain centralization. The rationale for studying monocytes is based on rodent models showing that monocytes are involved in maintaining chronic pain.
 
The hypothesis is that uniquely characteristic patterns of gene expression are associated with pain centralization. The specific aims are to:
  • Identify gene expression signatures in monocytes associated with pain centralization.
  • Establish if the gene expression profiles predict pain after treatment with disease-modifying antirheumatic drugs (DMARDs).
 
Fifty subjects with RA will be assessed before starting a DMARD and 12 weeks after completing it. Subjects will complete surveys to characterize their pain experience and undergo quantitative sensory testing (QST) to assess patterns of pain sensitivity associated with specific pain pathways. Blood will be drawn to collect monocytes for RNA-sequencing. Machine-learning techniques will be used to model if gene expression is associated with QST patterns of pain centralization and if it can predict pain response after DMARD therapy.
 
This research is innovative because it uses cutting-edge functional genomic approaches to identify pathways associated with chronic pain in RA and because it uses QST, in addition to self-reported measures of pain, to assess pain centralization.
 
This research is impactful because it would enable the development of non-opioid analgesics for chronic pain in patients with RA. This proposal aligns with the Foundation’s goal to support research that studies biological parameters associated with clinical manifestations and responses to therapy.
Headshot of Dr. Deborah Winter
Yvonne C. Lee, MD, MMSc, is the Helen Myers McLoraine Professor of Rheumatology, and associate professor of Medicine (Rheumatology) and Preventive Medicine at Northwestern Medicine.

Refer a Patient

Northwestern Medicine welcomes the opportunity to partner with you in caring for your patients. ​
Call 844.344.6663
Find an NM Rheumatologist

You May Also Like

Headshot of Dr. Arthur Mandelin

July 2021

RHEUMATOLOGY
Does a Mobile App to Monitor RA Symptoms Improve Disease Activity?
Image of woman holding cell phone

November 2021

RHEUMATOLOGY
Functional Genomics for Precision Medicine in Rheumatoid Arthritis and Scleroderma
immune cells

February 2022

RHEUMATOLOGY
COVID-19 Vaccination and Rheumatic Disease

Northwestern Medicine Breakthroughs for Physicians

About Us     Terms of Use     Privacy Policy     How to Vote for U.S. News & World Report Best Hospitals
© 2025 Northwestern Medicine® and Northwestern Memorial HealthCare. 
Northwestern Medicine® is a trademark of Northwestern Memorial HealthCare, used by Northwestern University
Connect with us
[email protected]
International physicians, contact [email protected]
  • Home
  • Specialties
    • Cardiovascular >
      • Research
      • Clinical Breakthroughs
      • News
    • Endocrinology >
      • Clinical Breakthroughs In Endocrinology
      • Research In Endocrinology
      • News
    • ENT (Otolaryngology) >
      • Clinical Breakthroughs
      • Research
      • News
    • Gastroenterology >
      • Clinical Breakthroughs
      • Research
      • News
    • Geriatrics >
      • Clinical Breakthroughs
      • Research
      • News
    • Neurosciences >
      • Rare and Complex Brain Tumors
      • Research
      • COVID-19 and Neurosciences
      • News
      • Clinical Breakthroughs
    • OB-GYN >
      • Clinical Breakthroughs
      • Research
      • News
    • Oncology >
      • Clinical Breakthroughs
      • Research
      • News
    • Ophthalmology >
      • Clinical Breakthroughs
      • Research
      • News
    • Organ Transplant >
      • Clinical Breakthroughs
      • Research
      • News
    • Orthopaedics >
      • Clinical Breakthroughs
      • Research
      • News
    • Psychiatry >
      • Clinical Breakthroughs
      • Research
      • News
    • Pulmonary >
      • Clinical Breakthroughs
      • Research
      • News
    • Rehabilitation >
      • Clinical Breakthroughs
      • News
    • Rheumatology >
      • Clinical Breakthroughs
      • Research
      • News
    • Urology >
      • Clinical Breakthroughs
      • Research
      • News
  • CME
  • REFERRALS
    • Refer to NM Cardiovascular
    • Refer to NM Neurosciences
    • Refer to Other Specialties