March 2022

ENT

ENDOTYPES OF CHRONIC RHINOSINUSITIS: RELATIONSHIPS TO DISEASE PHENOTYPES, PATHOGENESIS, CLINICAL FINDINGS, AND TREATMENT APPROACHES

Featuring: ​ Atsushi Kato, PhD, Anju Tripathi Peters, MD, Whitney W Stevens, MD, PhD, Robert P Schleimer, PhD, Bruce K Tan, MD, Robert C Kern, MD
​
Read the full study here.

​​​Abstract
Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant morbidity and costs to our health system. The study of CRS has progressed from an era focused on phenotype to include endotype-based information. Phenotypic classification has identified clinical heterogeneity in CRS based on endoscopically observed features such as presence of nasal polyps, presence of comorbid or systemic diseases, and timing of disease onset. More recently, laboratory-based findings have established CRS endotype based upon specific mechanisms or molecular biomarkers. Understanding the basis of widespread heterogeneity in the manifestations of CRS is advanced by findings that the three main endotypes, Type 1, 2, and 3, orchestrate the expression of three distinct large sets of genes. The development and use of improved methods of endotyping disease in the clinic are ushering in an expansion of the use of biological therapies targeting Type 2 inflammation now and perhaps other inflammatory endotypes in the near future. The purpose of this review is to discuss the phenotypic and endotypic heterogeneity of CRS from the perspective of advancing the understanding of the pathogenesis and improvement of treatment approaches and outcomes.

​
​
This abstract was originally published in the European Journal of Allergy and Clinical Immunology on March, 2022. ​
Atsushi Kato, PhD, assistant professor of Allergy and Immunology in the Department of Medicine and Otolaryngology - Head and Neck Surgery. 
Robert P Schleimer, PhD, Roy and Elaine Patterson Professor of Medicine and professor of Allergy and Immunology in the Department of Medicine, Microbiology-Immunology, 
​and Otolaryngology - Head and Neck Surgery.
Bruce K Tan, MD, associate professor of Otolaryngology - Head and Neck Surgery and Allergy and Immunology in the Department of Medicine.
Robert C Kern, MD, chair of the department of Otolaryngology - Head and Neck Surgery, George A. Sisson, MD, and professor of Otolaryngology - Head and Neck Surgery and Allergy and Immunology in the Department of Medicine.

Refer a Patient

Northwestern Medicine welcomes the opportunity to partner with you in caring for your patients. ​

You May Also Like