December 2023

NEUROSCIENCES

A NOVEL BRAF::PTPRN2 FUSION IN MENINGIOMA: A CASE REPORT

Featuring: Craig M. Horbinski, MD, PhD, and Stephen T. Magill, MD, PhD

A cavernous sinus and sphenoid wing mass was revealed by the brain images of an adult female presenting with episodic partial seizures characterized by déjà vu, confusion and cognitive changes. The patient underwent a resection, revealing a World Health Organization grade 1 meningioma.

Gene fusion events have been linked to oncogenesis in many cancers, but are understudied in meningioma compared to somatic mutations, chromosomal gains/losses and epigenetic changes. Fusions involving B-raf proto-oncogene, serine/threonine kinase (BRAF) are subtypes of oncogenic BRAF genetic abnormalities that have been reported in certain cases of brain tumors, such as pilocytic astrocytomas.

However, BRAF fusions have not been recognized in meningioma. This report raises the possibility that gene fusion events may be involved in meningioma pathogenesis and warrant further investigation.

Learn more about the case.
Craig M. Horbinski, MD, PhD, Assistant Professor of Neurological Surgery at Northwestern Medicine
Stephen T. Magill, MD, PhD, Assistant Professor of Neurological Surgery at Northwestern Medicine

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