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​Breakthroughs for Physicians

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Rare and Complex Brain Tumors​

DRIVING BREAKTHROUGHS IN RESEARCH AND TREATMENT OF RARE AND COMPLEX BRAIN TUMORS

Lou and Jean Malnati Brain Tumor Institute of Robert H. Lurie Comprehensive Cancer Center of Northwestern University at Northwestern Memorial Hospital offers comprehensive, leading-edge care for patients with primary or metastatic tumors of the brain or spine. Our scientists have pioneered therapies and developed better standards of care. They specialize in rare and challenging tumors, including:
  • Chordoma
  • Glioblastoma
  • Hemangioblastoma (Von Hippel Lindau disease)
  • Leptomeningeal metastases
  • Low grade glioma
  • Pleomorphic xanthoastrocytoma
 
We are proud to be one of the first institutions in the world to use DNA methylation profiling to diagnose brain tumors.

Refer a Patient

Northwestern Medicine Malnati Brain Tumor Institute welcomes the opportunity to collaborate with you on the care of your patients. To refer a patient, call 833.88.BRAIN (833.882.7246).

Meet the Malnati Brain Tumor Institute Team

Our team includes experts who specialize in virtually every type of brain tumor, including rare and complex tumors. We welcome the opportunity to collaborate with you on the care of your patients.

Meet the Experts

The Neurology and Neurosurgery, and Cancer Programs at Northwestern Memorial Hospital are proud to be among the top-ranked in the U.S.*

*Northwestern Memorial Hospital by U.S. News & World Report, 2025 – 26


 

clinical TRIALS AND rESEARCH

Through the Malnati Brain Tumor Institute of the Lurie Cancer Center, we offer one of the largest portfolios of brain tumor clinical trials in the Midwest, giving our patients with rare or complex tumors access to therapies that are not yet widely available. To view all of the brain and spine tumor clinical trials that we offer, click here.
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June 2024

NEUROSCIENCES
New Glioblastoma Treatment Reaches Human Brain Tumor and Helps Immune Cells Recognize Cancer Cells
In a recent study published in Nature Communications, Northwestern Medicine scientists, including Adam Sonabend, MD, used ultrasound technology to penetrate the blood-brain barrier to deliver a small dose of a chemotherapy and immunotherapy drug cocktail into the brain, a major advance for the treatment of glioblastoma.​
Dr. Koralnik

August 2023

NEUROSCIENCES
Brain Tumor SPORE Receives $10.8 Million NCI Award Renewal
Headshot of Dr. Mencacci

June 2024

NEUROSCIENCES
Drug Reprograms Immune Responses to Target Glioblastoma
Amy Heimberger, MD headshot

March 2024

NEUROSCIENCES
New Drug Shows Promise for Treating Rare Brain Tumors

PODCASTS

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November 2023

NEUROSCIENCES
Using Gene Expression to Predict if a Brain Tumor is Likely to Grow Back
Stephen Magill, MD, PhD, was co-senior author of a study published in Nature Medicine that discovered a highly accurate way to predict the best treatment for meningioma based on patterns of gene expression in the tumor. 
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March 2022

NEUROSCIENCES
Rare Central Nervous System Tumors: Progress in Clinical Care and Research
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April 2022

NEUROSCIENCES
Pet Dogs Advance Glioblastoma Research-Amy Heimberger, MD
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November 2022

NEUROSCIENCES
Von Hippel-Lindau Disease: Clinical Update and New Drug Therapy
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September 2023

NEUROSCIENCES
Shedding Light on Primary Vitreoretinal Lymphoma
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May 2022

NEUROSCIENCES
Chordoma: En Bloc Resection and Other Management Strategies
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April 2023

NEUROSCIENCES
Clinical Management of Low Grade Glioma

​VIDEOS

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March 2022

NEUROSCIENCES
Approach to Focal Epilepsy Secondary to Dominant Temporal Low Grade Gliomas
Jessica W. Templer, MD, assistant professor of Neurology (Epilepsy/Clinical Neurophysiology) at Northwestern Medicine, discusses the approach to patients with epilepsy secondary to a suspected low grade glioma and patient selection for intraoperative ECoG and awake craniotomies.
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July 2021

NEUROSCIENCES
Immunotherapy for Brain Tumors
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January 2022

NEUROSCIENCES
DNA Methylation Profiling: A Groundbreaking Diagnostic Tool for Brain Tumors
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August 2024

NEUROSCIENCES
Case Report: IDH-Mutant Grade II Oligodendroglioma

Follow MALNATI BRAIN TUMOR INSTITUTE

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CONTACT Malnati Brain Tumor Institute

We welcome referrals and offer second opinions for patients with rare and complex tumors. Our team of specialists will collaborate with you to develop an individualized care plan to optimize treatment and the patient experience. When options are limited, our experienced team can often provide innovative therapies and novel treatments through a wide variety of clinical trials.
 
We offer 24/7 consultation with highly experienced brain and spinal tumor experts, and simplified, around-the-clock patient transfers. Contact us any time, any day.
 
Call 833.88.BRAIN (833.882.7246) and
• Select 1 to transfer a patient.
• Select 2 to make an appointment for a new patient.
• Select 3 to immediately access one of our expert physicians.

​You can also request a consultation online. We’ll respond within 24 hours, and usually sooner.

Northwestern Medicine Breakthroughs for Physicians

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  • Home
  • Specialties
    • Cardiovascular >
      • Research
      • Clinical Breakthroughs
      • News
    • Endocrinology >
      • Clinical Breakthroughs In Endocrinology
      • Research In Endocrinology
      • News
    • ENT (Otolaryngology) >
      • Clinical Breakthroughs
      • Research
      • News
    • Gastroenterology >
      • Clinical Breakthroughs
      • Research
      • News
    • Geriatrics >
      • Clinical Breakthroughs
      • Research
      • News
    • Neurosciences >
      • Rare and Complex Brain Tumors
      • Research
      • COVID-19 and Neurosciences
      • News
      • Clinical Breakthroughs
    • OB-GYN >
      • Clinical Breakthroughs
      • Research
      • News
    • Oncology >
      • Clinical Breakthroughs
      • Research
      • News
    • Ophthalmology >
      • Clinical Breakthroughs
      • Research
      • News
    • Organ Transplant >
      • Clinical Breakthroughs
      • Research
      • News
    • Orthopaedics >
      • Clinical Breakthroughs
      • Research
      • News
    • Psychiatry >
      • Clinical Breakthroughs
      • Research
      • News
    • Pulmonary >
      • Clinical Breakthroughs
      • Research
      • News
    • Rehabilitation >
      • Clinical Breakthroughs
      • News
    • Rheumatology >
      • Clinical Breakthroughs
      • Research
      • News
    • Urology >
      • Clinical Breakthroughs
      • Research
      • News
  • CME
  • REFERRALS
    • Refer to NM Cardiovascular
    • Refer to NM Neurosciences
    • Refer to Other Specialties