March 2021 EXPLORING THE RELATIONSHIP BETWEEN MULTILAYERED CHOROIDAL NEOVASCULARIZATION AND CHORIOCAPILLARIS FLOW DEFICITS IN AMDAmani A. Fawzi, MD, the Cyrus Tang and Lee Jampol Professor of Ophthalmology, and colleagues at Northwestern Medicine were the first to report eyes with greater three-dimensional (3-D) complexity of choroidal neovascular (CNV) membranes as characterized by optical coherence tomography angiography are associated with the need for more frequent long-term anti-VEGF therapy. In a recent study published in Investigative Ophthalmology and Visual Science, Dr. Fawzi's team discovered the severity of choriocapillaris flow deficits in the area surrounding CNV membranes in AMD is associated with greater CNV complexity. This important work provides additional evidence of the importance of choriocapillaris dysfunction in neovascular AMD, as well as the potential role of choroidal ischemia in the pathogenesis of complex CNV membranes.
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Amani Fawzi, MD, is the Cyrus Tang and Lee Jampol Professor of Ophthalmology at Northwestern Medicine.
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