The brain is indeed a target for treating ALS (amyotrophic lateral sclerosis), Northwestern Medicine scientists have discovered. This flips a long-standing belief that the disease starts in the spinal motor neurons and any therapy would need to target the spine as the key focus.
A new Northwestern Medicine study published in Nature Gene Therapy shows the degeneration of brain motor neurons is not merely a byproduct of the spinal motor neuron degeneration, as had been previously thought.
Lead study author P. Hande Ozdinler, PhD, associate professor of Neurology at Northwestern Medicine, explains the findings in a recent Better Edge podcast.
Listen to the podcast >
Read the article in the Northwestern University Feinberg School of Medicine News Center .
Hande Ozdinler, PhD, is an associate professor of Neurology in the Division of Neuromuscular Disease at Northwestern Medicine.
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