Featuring: Scott Budinger, MD and Richard Wunderink, MD
COVID-19 pneumonia spreads like multiple wildfires, leaving destroyed lung tissue in its wake.
Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung within hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body’s immune system within the first few days of the illness.
But in a study published in Nature, Northwestern Medicine investigators have shown how COVID-19 pneumonia is different.
Instead of rapidly infecting large regions of the lung, the virus causing COVID-19 sets up shop in multiple small areas of the lung. It then hijacks the lungs’ own immune cells and uses them to spread across the lung over a period of many days or even weeks, like multiple wildfires spreading across a forest. As the infection slowly moves across the lung, it leaves damage in its wake and continuously fuels the fever, low blood pressure and damage to the kidneys, brain, heart and other organs in patients with COVID-19.
The severe complications of COVID-19 compared with other pneumonias might be related to the long course of disease rather than more severe disease, the study authors said.
This is the first study in which scientists analyzed immune cells from the lungs of COVID-19 pneumonia patients in a systematic manner and compared them to cells from patients with pneumonia from other viruses or bacteria.
Drug trial to treat newly discovered targets in COVID-19 pneumonia
As a result of the detailed analysis, the investigators identified critical targets to treat severe SARS-CoV-2 pneumonia and lessen its damage. The targets are the immune cells: macrophages and T cells. The study suggests macrophages – cells typically charged with protecting the lung – can be infected by SARS-CoV-2 and can contribute to spreading the infection through the lung.
Northwestern Medicine will test an experimental drug to treat these targets in COVID-19 pneumonia patients in a clinical trial in early 2021. The drug to be tested quiets the inflammatory response of these immune cells, thus enabling initiation of the repair process in the injured lung.
Aim to make COVID-19 like a bad cold
“Our goal is to make COVID-19 mild instead of severe, making it comparable to a bad cold,” said study co-senior author Scott Budinger, MD, chief of Pulmonary and Critical Care in the Department of Medicine and a Northwestern Medicine physician.
“This effort truly represents a ‘moonshot’ in COVID-19 research,” said study co-senior author Richard Wunderink, MD, professor of Pulmonary and Critical Care in the Department of Medicine and medical director of the Northwestern Medicine ICU.
COVID-19 unlikely to completely disappear
COVID-19, like influenza, is unlikely to ever go away, even if much of the population is vaccinated, said senior co-author Ben Singer, ’07 MD, ’10 GME, assistant professor of Pulmonary and Critical Care in the Department of Medicine and a Northwestern Medicine physician.
“Already, scientists at Northwestern and elsewhere are anticipating mechanisms by which this RNA virus, which mutates quickly, will evade current vaccines,” Singer said. “This study will help us develop treatments to reduce the severity of COVID-19 in those who develop it.”
Mortality in COVID-19 patients on ventilators lower than regular pneumonia patients
The study also revealed why the mortality among patients on a ventilator for COVID-19 was lower than patients on a ventilator due to regular pneumonia. An intense conflagration in the lungs (regular pneumonia) has a higher risk of death. Those with COVID-19 pneumonia are sick for a long time, but the inflammation in their lungs is not as severe as regular pneumonia.
“If patients with COVID-19 are carefully managed and the healthcare system isn’t overwhelmed, you can get them through it,” Budinger said. “These patients are very sick. It takes a really long time for them to get better. But if you have enough beds and health care providers, you can keep the mortality to 20 percent. When health systems are overwhelmed, mortality rates double up to 40 percent.”
For the study, scientists performed a high-resolution analysis of the lung fluid of 86 COVID-19 patients on a ventilator and compared it with lung fluid from 256 patients on a ventilator who had other types of pneumonia. Because of the safety concerns, only a handful of groups around the world performed analysis of the immune response in the lungs of patients with COVID-19. As a result, important information about what was killing patients with severe COVID-19 was missing.
Northwestern scientists, studying pneumonia for years, poised for COVID lung research
The study performed at Northwestern Medicine hospitals is unique because Wunderink and colleagues have been studying pneumonia for years before the pandemic. As a result, when the COVID-19 pandemic hit, they were prepared to collect fluid from the lungs of these patients in a safe and systematic manner and compare it with fluid from other ICU patients with pneumonia collected before the pandemic. This research infrastructure allowed them to show that pneumonia in patients with COVID-19 is different from other pneumonia, and more importantly, how it is different.
Scientists took cells from patients’ lung fluid and looked at the RNA and the proteins those cells express, enabling them to identify how these immune cells drive inflammation.
“This level of resolution could never be achieved without directly sampling lung fluid,” said study co-senior author Alexander Misharin, MD, PhD, assistant professor of Medicine in the Division of Pulmonary and Critical Care and a Northwestern Medicine physician.
The complex nature of the study, in which samples from patients were analyzed with the most sophisticated technologies available in Northwestern’s state-of-the art research labs, required the concerted effort of more than 100 scientists.
The first authors are Rogan Grant, Luisa Morales-Nebreda and Nikolay Markov, PhD. Grant is a graduate student in the Northwestern University Interdepartmental Neuroscience program; Luisa Morales-Nebreda, MD, is a pulmonary and critical care fellow at Northwestern; Markov, is a computational postdoctoral fellow in the Division of Pulmonary and Critical Care in the Department of Medicine.
The work was done as part of a consortium of investigators participating in the Successful Clinical Response in Pneumonia Therapy (SCRIPT) systems biology center funded by the National Institute of Allergy and Infectious Diseases, led by Wunderink.
The research was supported by a Northwestern University Clinical and Translational Sciences (NUCATS) Institute COVID-19 Rapid Response grant and grants T32AG020506-18, T32HL076139, F32HL151127, HL145478, HL147290, HL147575, GM129312, HL134800, U19AI135964, P01AG049665, P01AG04966506S1, R01HL147575, I01CX001777, U19AI135964, P01AG049665, R56HL135124, R01HL153312, K08HL128867, U19AI135964, R01HL149883 and P01AG049665 from the National Institutes of Health. It also was funded by a GlaxoSmithKline Distinguished Scholar in Respiratory Health grant from the CHEST Foundation.
This article was originally published in the Feinberg School of Medicine News Center on January 11, 2021 .
Scott Budinger, MD is the Chief of Pulmonary and Critical Care in the Department of Medicine, Ernest S. Bazley Professor of Airway Diseases and Professor of Medicine (Pulmonary and Critical Care) and Cell and Developmental Biology.
Richard Wunderink, MD research interests revolve around understanding the risk factors, including host genetic risk, and improving outcomes of critically ill patients with serious infections. This includes severe community-acquired pneumonia, sepsis of all causes, and nosocomial infections, particularly ventilator-associated pneumonia.
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