Featuring: Sadiya Khan, MD, MSc
Higher rates persist even after adjusting for age differences at pregnancy
The finding is significant because it is commonly thought that increases in rates of high blood pressure during pregnancy is due to people becoming pregnant at older ages. However, the study newly finds rates of high blood pressure during pregnancy are higher among individuals from more recent generations regardless of their age during pregnancy.
“While there are many reasons for the generational changes observed, we hypothesize that this is, in large part, due to the observed generational decline in heart health,” said corresponding study author Sadiya Khan, ’09 MD, ’14 MSc, ’10, ’12 GME, an assistant professor of Medicine in the Division of Cardiology at Northwestern University Feinberg School of Medicine and a Northwestern Medicine physician. “We are seeing more people in more recent generations entering pregnancy with risk factors such as obesity.”
The stakes are high, Khan said.
“High blood pressure during pregnancy is a leading cause of death for both mom and baby,” Khan said. “High blood pressure during pregnancy is associated with increased risk of heart failure and stroke in the mother, and increased risk of the baby being born prematurely, being growth restricted or dying.”
Previous research from Northwestern and the Centers for Disease Control and Prevention has highlighted the near doubling in rates of hypertension in pregnancy over the past decade.
More than a million millennials have already been diagnosed with high blood pressure during their first pregnancies, Khan said. In the four generations studied, racial and ethnic disparities have also persisted. The new Northwestern study found the highest rates of high blood pressure during pregnancy were among those who identified as non-Hispanic American Indian/Alaskan Native and non-Hispanic Black.
“This is the first multi-generational study that moves beyond the age of the mom or the calendar year of the delivery to understand patterns of hypertension in pregnancy,” Khan said. “This is especially important when we look at the legacy of substantial racial and ethnic disparities in this high-risk condition that affects not only the mom but also the baby. This sets up a vicious cycle of generational health decline by starting life with poorer heart health.”
“The public health and clinical message from this work is the need to broaden our perspective on screening and expand our focus on prevention in all age groups before and during pregnancy, particularly among younger people who have traditionally not been considered at high risk,” said study lead author Natalie Cameron, MD, ’21 GME, an instructor of Medicine in the Division of General Internal Medicine at Feinberg and a Northwestern Medicine physician.
Khan said mobile health technologies (e.g., wearables) and telehealth/remote health opportunities have opened opportunities to equitably improve surveillance for blood pressure.
“Prevention and earlier identification can be life-saving and improve the health of future generations beginning at birth,” Khan said.
The study was conducted using data from the National Vital Statistics System Natality Database, which contains information from birth certificates for all live births in the United States. The study focused on first pregnancies to individuals between 1995-2019 and included data from more than 38 million people. Using these data, investigators were able to determine rates of hypertensive disorders of pregnancy grouped by the mother’s birth year (maternal birth cohort) and their self-identified race or ethnicity.
Other Northwestern authors include Lucia Petito, PhD; Nilay Shah ’14 MD, ’14 MPH; Amanda Perak, ’09 MD, ’18 MS; Donald Lloyd-Jones, MD, ScM; and Philip Greenland, MD.
This research was supported by grant 1R01HL161514 from the National Heart, Lung, and Blood Institute of the National Institutes of Health.
This article was originally published in the Feinberg School of Medicine News Center on September 12, 2022.
Sadiya Khan, MD, MSc, 09 MD, ’14 MSc, ’10, ’12 GME, assistant professor of Medicine in the Division of Cardiology and of Preventive Medicine in the Division of Epidemiology, was lead author of the study published in Circulation.
Natalie Cameron, MD, ’21 GME, an instructor of Medicine in the Division of General Internal Medicine , was lead author of the study.
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