March 2026

UROLOGY

BRIGHT TRIAL AIMS TO BETTER PRESERVE BLADDER FUNCTION IN MUSCLE-INVASIVE BLADDER CANCER

Joshua Meeks, MD, PhD, discusses S2427 (BRIGHT) — a newly activated SWOG bladder preservation trial for patients with muscle-invasive bladder cancer. Dr. Meeks outlines the rationale behind shifting from cystectomy to bladder preservation in patients with a strong response to neoadjuvant therapy. He reviews key eligibility criteria and summarizes the single-arm trial design using trimodal therapy with pembrolizumab. 
Joshua Meeks, MD, PhD, the Edward M. Schaeffer, MD, PhD Professor of Urology, and Associate Professor of Urology at Northwestern Medicine

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