May 2026

NEUROSCIENCES

THE STUPP PROTOCOL AND EVOLUTIONS IN GLIOBLASTOMA MANAGEMENT

Nearly two decades after the introduction of combined radiation therapy and temozolomide, the Stupp protocol remains the foundation of glioblastoma treatment. In this episode, Roger Stupp, MD, and Rimas Lukas, MD, take a look at how this regimen emerged as a durable standard of care and how clinical insights since then have refined its use.
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Dr. Stupp and Dr. Lukas walk through the modern care pathway for newly diagnosed glioblastoma and the clinical trial landscape. They dive into why survival gains remain limited and what may move the field forward. 
Roger Stupp, MD, the Paul C. Bucy Professor of Neurological Surgery, Co-director of Lou & Jean Malnati Brain Tumor Institute, Chief of Neuro-oncology, Professor of Hematology and Oncology, and Associate Director for Strategic Initiatives at Northwestern Medicine
Rimas Lukas, MD, Vice Chair of Outpatient Neurology and Professor of Neuro-oncology and Hospital Neurology at Northwestern Medicine 

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