June 2025

NEUROSCIENCES

PARANEOPLASTIC SYNDROMES: INSIGHTS FROM AAN 2025

​Featuring: Ditte Primdahl, MD, and Shailee S. Shah, MD

Episode Summary

In this episode of Better Edge, Northwestern Medicine Neurologist Shailee S. Shah, MD, and Neuro-oncologist Ditte Primdahl, MD, unpack the latest advancements in paraneoplastic syndrome management, highlighted at the 2025 American Academy of Neurology Annual Meeting.
 
Together, they explore:
  • The complex interplay between immune checkpoint inhibitors and autoimmune neurologic syndromes
  • Emerging therapies, including CD19-directed CAR T-cell treatments
  • Updates to diagnostic criteria and risk stratification using high-risk autoantibodies
  • The role of predictive biomarkers and advanced omics in diagnosis
  • The launch of a dedicated paraneoplastic clinic at Northwestern Medicine
Ditte Primdahl, MD, Assistant Professor of Neurology (Neuro-oncology) and of Neurological Surgery at Northwestern Medicine
Shailee S. Shah, MD, Clinical Assistant Professor of Neurology (MS/Neuroimmunology) at Northwestern Medicine

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