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April 2025

NEUROSCIENCES
OPHTHALMOLOGY

ADDRESSING VISUAL SYMPTOMS IN MULTIPLE SCLEROSIS: A 5-PART SERIES

Neena Cherayil, MD, and Elena Grebenciucova, MD, joined a five-part series on NeurologyLive, to discuss how multiple sclerosis (MS) affects vision.

Part 1: Role of Neuro-Ophthalmologists in Care Paradigm of Multiple Sclerosis
  • Provides context on the role of neuro-ophthalmologists in the multidisciplinary care of MS, particularly in managing optic neuritis
  • Emphasizes how neuro-ophthalmologists' specialized tools and expertise help diagnose visual symptoms and differentiate MS from similar conditions

Part 2: Impact of Optic Nerve Inclusion on Early MS Diagnosis and Treatment
  • Discusses the benefits of incorporating optic nerve involvement into the diagnostic criteria for MS, particularly the McDonald criteria
  • Highlights how the inclusion of optic nerve lesions as part of dissemination in time and space improves diagnostic sensitivity and allows for earlier treatment initiation

Part 3: Educating the Clinical Community on Changes to MS Diagnostic Criteria
  • Discusses the education clinicians need to apply the latest changes in MS diagnostic criteria, focusing on integrating optic neuritis and the central vein sign into diagnostic criteria
  • Highlights the importance of distinguishing MS-related optic neuritis from conditions like neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)

Part 4: Challenges in Diagnosing Optic Neuritis in MS and MOGAD
  • Explores the complexities of diagnosing and managing visual symptoms in MS and related disorders such as MOGAD
  • Highlights challenges like recognizing subtle optic neuritis presentations and the importance of MRI quality and timing
  • Emphasizes the crucial role of neuro-ophthalmological evaluations and the importance of more focus on visual impairments in MS care

Part 5: Bridging Neurology and Ophthalmology in Multiple Sclerosis Research
  • Discusses the role of optical coherence tomography (OCT) in diagnosing optic neuropathy in MS and the need for further research
  • Highlights the potential of OCT and imaging techniques like neurofilament analysis to predict treatment responses and improve outcomes
Read More on how MS affects vision
Dr. Cherayil
Neena Cherayil, MD, Assistant Professor of Neurology and Ophthalmology at Northwestern Medicine

Dr. Grebenciucova
Elena Grebenciucova, MD, Assistant Professor of Neurology at Northwestern Medicine

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