May 2025

ENDOCRINOLOGY

AUTOMATED INSULIN DELIVERY LOWERS HBA1C IN TYPE 2 DIABETES

Featuring: ​ Grazia Aleppo, MD, Kasey J. Coyne, MD, Jelena Kravarusic, MD, PhD
In a recent study published in The New England Journal of Medicine, Northwestern Medicine endocrinologists Grazia Aleppo, MD, Kasey J. Coyne, MD, Jelena Kravarusic, MD, PhD, and other investigators examined the role of automated insulin delivery (AID) systems in the management of insulin-treated Type 2 diabetes. In the 13-week, randomized, controlled multicenter trial involving 319 adults, they found that AID systems effectively reduced glycated hemoglobin (HbA1c) levels and hyperglycemia without increasing hypoglycemia as compared to continuous glucose monitoring (CGM) alone.
Participants were randomly assigned in a 2:1 ratio to either receive the AID system or to continue their pretrial insulin delivery method as part of the control group. Both groups received CGM.
HbA1c levels decreased by 0.9 percentage points in the AID group and by 0.3 percentage points in the control group.
Read the full study >
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Grazia Aleppo, MD, Professor of Endocrinology at Northwestern Medicine
​Kasey J. Coyne, MD, Assistant Professor of Endocrinology at Northwestern Medicine
​Jelena Kravarusic, MD, PhD, Assistant Professor of Endocrinology at Northwestern Medicine

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