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< BACK TO CLINICAL BREAKTHROUGHS IN CARDIOVASCULAR

April 2026

CARDIOVASCULAR

HFPEF EXPLAINED — PREVALENCE, NEW ADVANCES AND HOW TO DIAGNOSE

Featuring: Sadiya S. Khan, MD, MSc, and Sanjiv J. Shah, MD
This first installment in a three-part educational miniseries from the New England Journal of Medicine explores heart failure with preserved ejection fraction (HFpEF) and how it differs from heart failure with reduced ejection fraction, along with its key risk factors and underlying pathophysiology. The discussion among several cardiologists highlights common diagnostic challenges and outlines a practical evaluation approach, including use of the H2FPEF score to help inform clinical decision-making.
WATCH PART 1
Mohamed Al-Kazaz, MD headshot
Sadiya S. Khan, MD, MSc, Magerstadt Professor of Cardiovascular Epidemiology, Associate Professor of Cardiology and of Epidemiology
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Sanjiv J. Shah, MD, the​ Neil J. Stone, MD, Professor of Cardiology, and the Director of Center for Deep Phenotyping and Precision Therapeutics in the Institute for AI in Medicine

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  • Home
  • Specialties
    • Cardiovascular >
      • Research
      • Clinical Breakthroughs
      • News
    • Endocrinology >
      • Clinical Breakthroughs In Endocrinology
      • Research In Endocrinology
      • News
    • ENT (Otolaryngology) >
      • Clinical Breakthroughs
      • Research
      • News
    • Gastroenterology >
      • Clinical Breakthroughs
      • Research
      • News
    • Geriatrics >
      • Clinical Breakthroughs
      • Research
      • News
    • Neurosciences >
      • Rare and Complex Brain Tumors
      • Research
      • COVID-19 and Neurosciences
      • News
      • Clinical Breakthroughs
    • OB-GYN >
      • Clinical Breakthroughs
      • Research
      • News
    • Oncology >
      • Clinical Breakthroughs
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    • Ophthalmology >
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    • Organ Transplant >
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    • Orthopaedics >
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    • Psychiatry >
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    • Pulmonary >
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    • Rehabilitation >
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    • Rheumatology >
      • Clinical Breakthroughs
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    • Urology >
      • Clinical Breakthroughs
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      • News
  • CME
  • REFERRALS
    • Refer to NM Cardiovascular
    • Refer to NM Neurosciences
    • Refer to Other Specialties